eng URI http://hdl.handle.net/10795/3690 ιατρικές επιστήμες βιολογικές επιστήμες βιοτεχνολογία γενετική μηχανική Recent studies support cell based therapies for several diseases. Human fetal stem cells have received much attention for developing new therapeutic strategies. Recently, our group and others have successfully isolated and expanded karyotypically normal stem cells from an alternative fetal source, the human second trimester amniotic fluid (AF) and performed a systematic phenotypic and molecular analysis. The main characteristics of amniotic fluid stem cells (hAFSCs) are their fetal origin, the high number of isolated cells, their wide differentiation properties and their rapid expansion in vitro. These characteristics render hAFSCs as a very attractive tool for clinical applications based on cell therapy. The use of hAFSC transplantation has been studied in a variety of disease animal models related to bone regeneration, myocardial infarction, acute kidney injury, acute hepatic failure, skin injury, ischemic hind limb or cancer. The major aim of this review is to summarize the advent of hAFSCs capabilities into novel therapeutic modalities and discuss their potential use in future pre-clinical and clinical studies. 8 pp. LOMv1.0 creator LOMv1.0 publisher LOMv1.0 Scientific Coordinator LOMv1.0 Project Executing Organisation 2013 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Amniotic fluid animal models cell transplantation c-Kit fetal stem cells MSCs stem cell therapy 143328 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3690/2/3690_1.134_%ce%94%ce%97%ce%9c_1_3_13.pdf URI http://hdl.handle.net/10795/3690 LOMv1.0creator 2016-06-21T09:21:19Z LOMv1.0validator 2016-06-21T09:21:19Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")