eng URI http://hdl.handle.net/10795/3653 ιατρικές επιστήμες ασθένεια του νευρικού συστήματος κυτταρολογία Background: The incidence and prevalence of CNS involvement in SLE remains unclear owing to conflicting results in the published studies. The aim of the study was to evaluate the incidence and prevalence of major definite CNS events in SLE patients. Methods: 370 SLE patients with no previous history of CNS involvement were prospectively evaluated in a tertiary hospital referral center for 3 years. Major CNS manifestations were codified according to ACR definitions, including chorea, aseptic meningitis, psychosis, seizures, myelopathy, demyelinating syndrome, acute confusional state and strokes. Minor CNS events were excluded. ECLAM and SLEDAI-SELENA Modification scores were used to evaluate disease activity and SLICC/ACR Damage Index was used to assess accumulated damage. Results: 16/370 (4.3%) patients presented with a total of 23 major CNS events. These included seizures (35%), strokes (26%), myelopathy (22%), optic neuritis (8.7%), aseptic meningitis (4.3%) and acute psychosis (4.3%). Incidence was 7.8/100 person years. Among hospitalizations for SLE, 13% were due to CNS manifestations. Epileptic seizures were associated with high disease activity, while myelopathy correlated with lower disease activity and NMO-IgG antibodies (P#0.05). Stroke incidence correlated with APS coexistence (P = 0.06). Overall, CNS involvement correlated with high ECLAM and SLEDAI scores (P,0.001). Conclusions: Clinically severe CNS involvement is rare in SLE patients, accounting for 7.8/100 person years. CNS involvement correlates with high disease activity and coexistence of specific features that define the respective CNS syndromes. 8 pp. LOMv1.0 creator LOMv1.0editor LOMv1.0 publisher LOMv1.0 Scientific Coordinator LOMv1.0 Project Executing Organisation 2013-02-12 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Central nervous system Systemic Lupus Erythematosus Autoimmune systemic diseases Neurological examination Antibodies Optic neuritis Κεντρικό νευρικό σύστημα Συστηματικός ερυθηματώδης λύκος Επιπολασμός Αντισώματα Οπτική νευρομυελίτιδα 243741 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3653/2/3653_1.106_%ce%94%ce%97%ce%9c_12_2_13.pdf URI http://hdl.handle.net/10795/3653 LOMv1.0creator 2016-06-15T14:23:10Z LOMv1.0validator 2016-06-15T14:23:10Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")