eng URI http://hdl.handle.net/10795/3341 φυσικές επιστήμες χημεία ιατρικές επιστήμες ασθένεια του νευρικού συστήματος προσομοίωση φαρμακευτική The present work describes the drug:membrane interactions and a drug delivery system of the novel potent AT1 blocker BV6. This designed analog has most of the pharmacological segments of losartan and an additional biphenyltetrazole moiety resulting in increased lipophilicity. We found that BV6:membrane interactions lead to compact bilayers that may in part explain its higher in vitro activity compared to losartan since such environment may facilitate its approach to AT1 receptor. Its high docking score to AT1 receptor stems from more hydrophobic interactions compared to losartan. X-ray powder diffraction (XRPD) and thermogravimetric analysis (TGA) have shown that BV6 has a crystalline form that is not decomposed completely up to 600 °C. These properties are desirable for a drug molecule. BV6 can also be incorporated into a mesoporous silicate drug-delivery matrix SBA-15. The properties of the obtained drug-delivery system have been inspected by XRD, 13C CP/MAS, TGA and nitrogen sorption experiments. 9 pp. LOMv1.0 creator LOMv1.0 publisher LOMv1.0 Scientific Coordinator LOMv1.0 Project Executing Organisation 2013-03-16 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Drug:membrane interaction AT1 antagonist BV6 Silicate matrix Dipalmitoylphosphatidylcholine Biophysical methodology 1174618 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3341/2/3341_1.153_%ce%94%ce%97%ce%9c_16_3_13.pdf URI http://hdl.handle.net/10795/3341 LOMv1.0creator 2016-05-23T11:23:43Z LOMv1.0validator 2016-05-23T11:23:43Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")