eng URI http://hdl.handle.net/10795/3295 ιατρική βιοχημεία κυτταρολογία Advanced Glycation End-products (AGEs) are produced by the non-enzymatic glycation of proteins, lipids and nucleic acids, resulting in an overload of highly reactive molecules of endogenous or exogenous (dietary) origin. Increased AGE levels in circulation and concomitant elevated tissue deposition have been associated with diabetic complications, atheromatosis, ageing and more recently with polycystic ovary syndrome pathogenesis. Interaction of AGEs with their receptor RAGE (Receptor for AGEs) activates intracellular signaling pathways which induce targeted gene expression in endothelium including upregulation of cell adhesion molecules and endothelin-1 (ET-1), implicated in vascular injury and endothelial dysfunction. The purpose of this study is to explore the molecular mechanism of AGE-induced regulation of ET-1 gene/protein expression in human endothelial cells and investigate its functional relevance in normal rat vascular endothelium. 1 pp. LOMv1.0 creator LOMv1.0 Scientific Coordinator LOMv1.0 Project Executing Organisation 2012-06-23 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Advanced Glycation End-products Polycystic ovary syndrome Endothelium Endothelial cells Μικροβιολογία Μοριακή βιολογία Γλυκοζυλίωση AGEs PCOS Κύτταρα Σύνδρομο πολυκυστικών ωοθηκών Ενδοθηλίνη 787337 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3295/2/3295_1.68_%ce%91%ce%9d_23_6_12.pdf URI http://hdl.handle.net/10795/3295 LOMv1.0creator 2016-05-20T11:09:54Z LOMv1.0validator 2016-05-20T11:09:54Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")