eng URI http://hdl.handle.net/10795/3059 βιοχημεία καρκίνος πρόληψη των ασθενειών Kallikrein-related peptidases (KLKs) form a cancer-related ensemble of serine proteases. This multigene family hosts the most widely used cancer biomarker that is PSA-KLK3, with millions of tests performed annually worldwide. The present report provides an overview of the biomarker potential of the extended KLK family (KLK1-KLK15) in various disease settings and envisages approaches that could lead to additional KLK-driven applications in future molecular diagnostics. Particular focus is given on the inclusion of KLKs into multifaceted cancer biomarker panels that provide enhanced diagnostic, prognostic and/or predictive accuracy in several human malignancies. Such panels have been described so far for prostate, ovarian, lung and colorectal cancers. The role of KLKs as biomarkers in non-malignant disease settings, such as Alzheimer’s disease and multiple sclerosis, is also commented upon. Predictions are given on the challenges and future directions regarding clinically oriented KLK research. 11 pp. LOMv1.0 creator LOMv1.0 publisher LOMv1.0 Scientific Coordinator LOMv1.0 Project Final Beneficiary LOMv1.0 Project Executing Organisation 2014 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Biomarker panel Cancer diagnosis Cancer prognosis Kallikrein-related peptidases KLK Molecular tumor marker Neurodegenerative diseases Ovarian cancer Prostate cancer PSA 230565 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3059/2/3059_EXPE%23NH9.pdf Άρθρο ανασκόπησης (review) URI http://hdl.handle.net/10795/3059 LOMv1.0creator 2016-05-09T09:32:20Z LOMv1.0validator 2016-05-09T09:32:20Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")