eng URI http://hdl.handle.net/10795/2622 βιοτεχνολογία βιοχημεία ένζυμο A major detoxification mechanism of the cell involves the glutathione transferase (GST)‐catalyzed formation of glutathione (GSH) conjugates with various xenobiotics Based on the same mechanism, GST overexpression may lead to multidrug resistant phenotypes Therefore, several compounds with inhibitory potency against GSTs have been developed as potential tools fortackling GST-­‐attributed MDR. Several individual compounds and prodrugs have been proposed as GST‐inhibiting substances. In addition, GSH analogues have been considered as specific GST inhibitors, with particular attention been directed towards the synthesis of GSH analogues stable against γ‐glutamyltranspeptidase (γGT) and peptidases, as GST inhibitors. 1 pp. LOMv1.0 creator LOMv1.0 Project Final Beneficiary LOMv1.0 Project Executing Organisation 2015 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Glutathione analogues Glutathione transferase MDR Multiple drug resistance 1502077 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/2622/2/2622_Poster%2010.pdf URI http://hdl.handle.net/10795/2622 LOMv1.0creator 2016-04-13T12:24:11Z LOMv1.0validator 2016-04-13T12:24:11Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")