eng URI http://hdl.handle.net/10795/1568 υλικά προηγμένης τεχνολογίας νανοτεχνολογία φαρμακευτική Insulin (INS) was incorporated into complexes with the block polyelectrolyte quaternized poly[3,5-bis(dimethylaminomethylene)hydroxystyrene]-b-poly(ethyleneoxide) (QNPHOSEO), which is a cationic-neutral block polyelectrolyte. Light scattering techniques are used in order to examine the size, the size distribution and the ζ-potential of the nanocarriers in aqueous and biological media, which are found to depend on the ratio of the components and the physicochemical parameters during and after complex preparation. Circular dichroism and infrared spectroscopy, employed to investigate the structure of the complexed INS, show no alteration of protein structure after complexation. In vitro release profiles of the entrapped protein are found to depend on the ratio of the components and the solution conditions used during preparation of the complexes. 31 pp. LOMv1.0 creator LOMv1.0subject matter expert LOMv1.0 Project Final Beneficiary LOMv1.0 Project Executing Organisation 2015 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Block polyelectrolyte Insulin Complexation process Stealthiness In vitro release studies 979524 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/1568/2/1568_Int%20J%20Pharm%202015%20136.pdf URI http://hdl.handle.net/10795/1568 LOMv1.0creator 2016-01-22T08:35:06Z LOMv1.0validator 2016-01-22T08:35:06Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")